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Image Search Results
Journal: NPJ Precision Oncology
Article Title: Detection of cytogenetically cryptic PML-RARA fusion in acute promyelocytic leukemia by rapid next generation sequencing
doi: 10.1038/s41698-025-01072-8
Figure Lengend Snippet: a Flow cytometry showed CD34 (+) and HLA-DR (+) which is not common in hypergranular acute promyelocytic leukemia; however, CD34 positivity can be seen in microgranular acute promyelocytic leukemia which is more consistent with this patient’s presentation. b Microgranular promyelocyte in peripheral blood (wright Giemsa stain). c Bone marrow core. d Negative RARA break apart probe set (Abbott Molecular, Inc.) to detect gene rearrangement at 17q12-q21 associated with acute promyelocytic leukemia (APL).
Article Snippet: Therefore, incorporating fast turn-around-time NGS testing into acute leukemia patient care empowers clinicians to make rapid biomarker-informed decision and improved outcomes Fig. 1 Histology, flow cytometry, immunohistochemistry and FISH results. a Flow cytometry showed CD34 (+) and HLA-DR (+) which is not common in hypergranular acute promyelocytic leukemia; however, CD34 positivity can be seen in microgranular acute promyelocytic leukemia which is more consistent with this patient’s presentation. b Microgranular promyelocyte in peripheral blood (wright Giemsa stain). c Bone marrow core.
Techniques: Flow Cytometry, Giemsa Stain